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Search Results for " ubiquitin-protein ligase "

Targets Recommended: Ligand for E3 Ligase

49

抑制剂 & 化合物

73

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br是Lenalidomide的衍生物，作为cereblon (CRBN)的配体，后者是参与蛋白质招募的E3泛素连接酶。通过连接器，Lenalidomide-Br可与蛋白质配体偶联，构建PROTACs。例如，Lenalidomide-Br被作为PROTAC STAT3降解剂SD-36的组成部分利用。
T13244	Ubiquitination-IN-1	Others	Others
	Ubiquitination-IN-1 是一种有效的泛素化和Cksl-Skp2蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂，增加 p27 水平，可通过阻断肿瘤抑制因子的降解发挥作用。
T12186	Navitoclax-piperazine ABT-263-piperazine	BCL; Ligands for Target Protein for PROTAC	Apoptosis; PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤(BCL-XL)抑制剂。它和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216。
T8929	BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy; Others; E1/E2/E3 Enzyme; AMPK	Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。
T31221	dBRD9 dBRD-9,dBRD 9	PROTACs	PROTAC
	dBRD9是一种 PROTAC。dBRD9是一种双重作用的分子，一部分连接 Bromodomain-containing protein 9 （BRD9）的溴域，另一部分招募小脑 E3泛素连接酶的配体（ligand that recruits the cereblon E3 ubiquitin ligase）。dBRD9对 MOLM-13细胞中 BRD9具有抑制作用，可使其降解，IC50为104 nM。
T17879	E3 ligase Ligand 8	Others; Ligand for E3 Ligase	Others; PROTAC
	E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。
T5821	BC-1215	Others; Ligand for E3 Ligase	Others; PROTAC
	BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
T17870	cIAP1 ligand 1 E3 ligase Ligand 12	Others	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体偶联开发蛋白降解剂，可用于研究前列腺癌。
T6763	Xevinapant ARRY-334543,SM-406,AT406,Debio-1143	IAP	Apoptosis
	Xevinapant (Debio-1143) 是一种有效的 Smac 模拟物和 IAP 的拮抗剂，能够抑制 XIAP，cIAP1 和 cIAP2 蛋白，Ki 值分别为 66.4，1.9 和 5.1 nM。
T18066	Lenalidomide-OH	Ligand for E3 Ligase	PROTAC
	Lenalidomide-OH是cereblon (CRBN)的配体，作为E3泛素连接酶的Lenalidomide类似物。它用于CRBN蛋白的招募。此外，通过连接器，Lenalidomide-OH可以与蛋白质配体结合，形成PROTACs。一个包含Lenalidomide-OH的PROTAC BTK降解剂的例子是SJF620。
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T23709	alphaSYN-IN-NAB2 alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2
	alphaSYN-IN-NAB2 是一种神经元保护剂，是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点，该节点可以纠正其潜在病理学的多个方面，包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程，可用来研究癌症、神经发育和神经元活动。
T14777	BRD5529	Others	Others
	BRD5529 is a selective inhibitor of CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction (IC50: 8.6 μM). BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and activation of CARD9.
T17868	E3 ligase Ligand 10	Others	Others
	E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
T17871	E3 ligase Ligand 13	Others	Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
T18636	PROTAC ERα Degrader-1	Others; PROTACs	Others; PROTAC
	PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα).
T17872	E3 ligase Ligand 14	Others	Others
	E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of cancer-promoting proteins[1].
T61642	CCW16
	CCW16 is a covalent ligand specifically designed for the E3 ubiquitin ligase RNF4. It serves as a valuable tool in the creation of protein degraders, facilitating the exploration of targeted protein degradation. [1]
T31523	Diptoindonesin G
	Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein level of ERα,
T69923	Brigimadlin BI 907828
	Brigimadlin (BI 907828) 是一种 E3 泛素蛋白连接酶 MDM-2抑制剂。Brigimadlin 可作为抗肿瘤剂。
T17876	E3 ligase Ligand 18	Others	Others
	E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-mediated degradation, targeting cancer-promoting proteins[1].
T40690	Azido-PEG3-chloroacetamide Azido-PEG3-chloroacetamide
	Azido-PEG3-chloroacetamide is a polyethylene glycol (PEG)-based linker. It serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating efficient conjugation between target protein-recruiting ligands and E3 ubiquitin ligase binders.
T17880	E3 ligase Ligand 9	Others	Others
	E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1].
T16659	Boc-NH-PEG2-C2-NH2 PROTAC Linker 13	Others	Others
	Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker utilized for the synthesis of PROTACs. This chemical compound plays a crucial role in connecting the targeted protein and the E3 ubiquitin ligase for selective protein degradation[1].
T38393	Ipatasertib-NH2 dihydrochloride RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride
	Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquitin ligase.
T17345	7-Octynoic acid	Others	Others
	7-Octynoic acid (compound 42) serves as a PROTAC linker for synthesizing various PROTACs, which are composed of two distinct ligands joined by this linker. One ligand interacts with an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
T11292	FKBP12 PROTAC dTAG-7 dTAG-7	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
T17884	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].
T18061	KB02-SLF	Others; PROTACs	Others; PROTAC
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1].
T17545	Biotin-BS	Others	Others
	Biotin-BS is a chemical compound composed of two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and biotin. These ligands are interconnected through linkers. MeBS serves as a ligand specifically for the cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].
T18630	Tos-PEG3-NH-Boc PROTAC Linker 9	Others	Others
	Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based linker utilized for the synthesis of PROTACs. It plays a critical role in facilitating the connection between a target protein and an E3 ubiquitin ligase, ultimately leading to the degradation of the target protein.
T39679	Lenalidomide-I
	Lenalidomide-I (Compound 72) is a derivative of the cereblon (CRBN) ligand, Lenalidomide, with affinity for E3 ubiquitin ligase. It facilitates the recruitment of CRBN protein. Lenalidomide-I can be utilized in PROTACs, such as the PROTAC BET degrader QCA570, by linking it to the targeted protein ligand through a linker.
T18053	Ipatasertib-NH2 RG7440-NH2,GDC-0068-NH2	Others	Others
	Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
T17894	cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 40	Others	Others
	cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].
T18543	Phthalimide-PEG4-MPDM-OH	Others	Others
	Phthalimide-PEG4-MPDM-OH, a PROTAC linker with a PEGs composition, has applications in the synthesis of various PROTACs. These PROTACs consist of a linker connecting two distinct ligands: one binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively induce the degradation of target proteins [1].
T18544	Phthalimide-PEG4-PDM-OTBS	Others	Others
	Phthalimide-PEG4-PDM-OTBS is a PROTAC linker comprised of polyethylene glycols (PEGs). This compound is utilized in the synthesis of a range of PROTACs, which consists of two distinct ligands connected by a linker. One ligand binds to an E3 ubiquitin ligase, while the other ligand binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
T17646	Boc-C1-PEG3-C4-OBn	Others	Others
	Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PEG-based PROTAC linker employed in the synthesis of various PROTACs, including PROTAC SGK3 degrader-1. PROTACs are composed of two distinct ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, while the other specifically interacts with the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs can selectively degrade target proteins[1].
T18542	Phthalimide-PEG3-C2-OTs	Others	Others
	Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker composed of PEGs. It is utilized in the synthesis of various PROTACs, which involve the connection of two distinct ligands through a linker. One ligand is specific for an E3 ubiquitin ligase, while the other ligand is designed for targeting the specific protein of interest. Through leveraging the intracellular ubiquitin-proteasome system, PROTACs are capable of selectively degrading target proteins [1].
T17647	Boc-C1-PEG3-C4-OH	Others	Others
	Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].
T11291	FKBP12 PROTAC dTAG-13 dTAG-13	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
T18060	KB02-JQ1	Others; PROTACs	Others; PROTAC
	KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link...
T74375	PROTAC ERα Y537S degrader-1
	PROTACERαY537S degrader-1 包含泛素 E3 连接酶结合基团，linker 和靶蛋白结合基团。PROTACERαY537S degrader-1 是雌激素受体-α (ERα) Y537S 的降解剂。
T73945	MAK683-CH2CH2COOH hydrochloride
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。
T78721	Smurf1-IN-1	E1/E2/E3 Enzyme	Ubiquitination
	SMURF1-IN-1是一种口服活性的特异性E3泛素蛋白连接酶1（SMURF1）选择性抑制剂，IC50值为92 nM。在大鼠肺部高压模型中显示出显著疗效，适用于肺动脉高压疾病的研究。
T74649	Rugonersen
	Rugonersen (RG6091; RO7248824) 是一种通过锁定核酸 (LNA) 技术修饰的反义寡核苷酸 (ASOs)，目的在于降低泛素蛋白连接酶 E3A (UBE3A) 的沉默。它被用于研究由于神经元 E3 连接酶 UBE3A 缺失所导致的严重神经发育障碍——Angelman 综合征 (AS)。
T13765	MAK683-CH2CH2COOH	Others	Others
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体，设计了靶向EED 的PROTACs， PROTAC EED degrader-1 和 PROTAC EED degrader-2 。
T18697	SNIPER(ER)-87	Others	Others
	SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
T36800	EN219
	EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and p21 ubiquitination in a cell-free assay when used at a concentration of 50 μM. EN219 (1 μM) also interacts with cysteine residues in the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60), also known as Hsp family D member 1 (HspD1), and histone H3.1 (HIST1H3A) in 231MFP hum...
T75133	NRX-0492
	NRX-0492 是一种口服有效的 BTK 降解剂。NRX-0492 催化 BTK 泛素化和蛋白酶体降解 (DC50≤0.2 nM，DC90≤0.5 nM)。NRX-0492 抑制 B 细胞受体 (BCR) 介导的信号、转录程序和趋化因子分泌。NRX-0492 能够把非共价 BTK 结合域连接到 Cereblon。Cereblon 是 E3泛素连接酶复合物的一种衔接蛋白。

化合物

Lenalidomide-Br

Cat.No: T18064

Target: Ligand for E3 Ligase

Ubiquitination-IN-1

Cat.No: T13244

Target: Others

Navitoclax-piperazine

Cat.No: T12186

Synonym: ABT-263-piperazine

Target: BCL, Ligands for Target Protein for PROTAC

Cat.No: T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Cat.No: T31221

Synonym: dBRD-9,dBRD 9

Target: PROTACs

E3 ligase Ligand 8

Cat.No: T17879

Target: Others, Ligand for E3 Ligase

Cat.No: T5821

Target: Others, Ligand for E3 Ligase

Cat.No: T17870

Synonym: E3 ligase Ligand 12

Target: Others

Cat.No: T6763

Synonym: ARRY-334543,SM-406,AT406,Debio-1143

Target: IAP

Lenalidomide-OH

Cat.No: T18066

Target: Ligand for E3 Ligase

Cat.No: T63790

Target: E1/E2/E3 Enzyme

alphaSYN-IN-NAB2

Cat.No: T23709

Synonym: alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2

Cat.No: T14777

Target: Others

E3 ligase Ligand 10

Cat.No: T17868

Target: Others

E3 ligase Ligand 13

Cat.No: T17871

Target: Others

PROTAC ERα Degrader-1

Cat.No: T18636

Target: Others, PROTACs

E3 ligase Ligand 14

Cat.No: T17872

Target: Others

Cat.No: T61642

Diptoindonesin G

Cat.No: T31523

Cat.No: T69923

Synonym: BI 907828

E3 ligase Ligand 18

Cat.No: T17876

Target: Others

Azido-PEG3-chloroacetamide

Cat.No: T40690

Synonym: Azido-PEG3-chloroacetamide

E3 ligase Ligand 9

Cat.No: T17880

Target: Others

Boc-NH-PEG2-C2-NH2

Cat.No: T16659

Synonym: PROTAC Linker 13

Target: Others

Ipatasertib-NH2 dihydrochloride

Cat.No: T38393

Synonym: RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride

7-Octynoic acid

Cat.No: T17345

Target: Others

FKBP12 PROTAC dTAG-7

Cat.No: T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain, PROTACs

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Cat.No: T17884

Synonym: E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

Target: Others

Cat.No: T18061

Target: Others, PROTACs

Cat.No: T17545

Target: Others

Tos-PEG3-NH-Boc

Cat.No: T18630

Synonym: PROTAC Linker 9

Target: Others

Cat.No: T39679

Ipatasertib-NH2

Cat.No: T18053

Synonym: RG7440-NH2,GDC-0068-NH2

Target: Others

cIAP1 Ligand-Linker Conjugates 3

Cat.No: T17894

Synonym: E3 ligase Ligand-Linker Conjugates 40

Target: Others

Phthalimide-PEG4-MPDM-OH

Cat.No: T18543

Target: Others

Phthalimide-PEG4-PDM-OTBS

Cat.No: T18544

Target: Others

Boc-C1-PEG3-C4-OBn

Cat.No: T17646

Target: Others

Phthalimide-PEG3-C2-OTs

Cat.No: T18542

Target: Others

Boc-C1-PEG3-C4-OH

Cat.No: T17647

Target: Others

FKBP12 PROTAC dTAG-13

Cat.No: T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T18060

Target: Others, PROTACs

PROTAC ERα Y537S degrader-1

Cat.No: T74375

MAK683-CH2CH2COOH hydrochloride

Cat.No: T73945

Cat.No: T78721

Target: E1/E2/E3 Enzyme

Cat.No: T74649

MAK683-CH2CH2COOH

Cat.No: T13765

Target: Others

Cat.No: T18697

Target: Others

Cat.No: T36800

Cat.No: T75133

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01035	UBE2G2 Protein, Human, Recombinant (GST) Ubiquitin-Conjugating Enzyme E2 G2,Ubiquitin	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked ...
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST) pellino E3 ubiquitin protein ligase	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages.
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST) SUMO-Protein Ligase,Ubiquitin-Con...	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin homologue, Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging.
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc) Rnf43,RING finger protein 43,RING-type E3 ubiqu...	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST) UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,U...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST) Ubiquitin-Conjugating Enzyme E2 D4,Ubiquitin	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process...
TMPJ-01198	UBE2R2 Protein, Human, Recombinant (His) UBC3B,Ubiquitin-Conjugating Enzyme E2-CDC34B,CDC34B...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2R2 catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in degradation of katenin.
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His) RAD6A,HR6A,Ubiquitin-Protein Ligase	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re...
TMPJ-01138	UBE2S Protein, Human, Recombinant (GST) UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui...
TMPJ-01334	UBE2Z Protein, Human, Recombinant (His) Uba6-Specific E2 Conjugating Enzyme 1,Ubiquitin Car...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. It is ubiquitinates proteins that catalyze the covalent attachment of ubiquitin to other proteins. It has shown that ZUBE2Z participate in signaling pathways, and may be involved in apoptosis regulation.
TMPJ-00571	UBE2D3 Protein, Human, Recombinant Ubiquitin-protein ligase D3,U...	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
TMPJ-01039	UBE2K Protein, Human, Recombinant (His & SUMO) Ubiquitin-Conjugating Enzyme E2-25 kDa,Huntingtin-I...	Human	E. coli
	UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086.
TMPJ-00033	UBE2B Protein, Human, Recombinant (His) Ubiquitin-Conjugating Enzyme E2 B,hHR6B,Ubiquit...	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18, UBR2, and WAC. UBE2B is required for post-replicative DNA damage repair. Additional, UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.
TMPJ-01038	UBE2K Protein, Human, Recombinant (GST) Ubiquitin-Conjugating Enzyme E2(25K),Ubiquitin<...	Human	E. coli
	UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086.
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST) Cbl proto-oncogene C, E3 ubiquitin protein...	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST) WW domain containing E3 ubiquitin protein ...	Human	Baculovirus Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6...
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST) Ubiquitin-conjugating enzyme E2(17)KB 1,UB,UbcH5,UB...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc...
TMPH-01259	AMFR Protein, Human, Recombinant (His) Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc) gp78,RNF45,AMF receptor,RING finger protein 45,E3 <...	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....
TMPY-06026	VHL Protein, Human, Recombinant (His & Avi) RCA1,HRCA1,pVHL,VHL1,von Hippel-Lindau tumor suppressor, E3 ...	Human	E. coli
	VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
TMPY-01216	XIAP Protein, Human, Recombinant (Avi) hIAP-3,IAP-3,MIHA,ILP1,BIRC4,hIAP3,API3,XLP2,X-linked inhibi...	Human	E. coli
	XIAP Protein, Human, Recombinant (Avi) is expressed in E. coli expression system with AVI tag. The predicted molecular weight is 29.1 kDa and the accession number is P98170.
TMPY-02922	XIAP Protein, Human, Recombinant (His) hIAP-3,API3,XLP2,ILP1,MIHA,X-linked inhibitor of apoptosis, ...	Human	E. coli
	XIAP Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P98170.
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
TMPY-04153	RNF43 Protein, Human, Recombinant (His) ring finger protein 43,URCC,RNF43,RNF124	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t...
TMPH-01204	DCAF4 Protein, Human, Recombinant (His & SUMO) DCAF4,DDB1- and CUL4-associated factor 4,WDR21,WDR21A,WD rep...	Human	E. coli
	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO44 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9H4M3.
TMPH-03526	Cap8A Protein, S. aureus, Recombinant (His) MAGEB2,MAGE XP-2 antigen,DAM6,MAGE-B2 antigen,Melanoma-assoc...	Staphylococcus aureus	E. coli
	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Cap8A Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is O15479.
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
TMPJ-01132	NEDD8 Protein, Human, Recombinant Ubiquitin-like protein Nedd8,NEDD8,Neddyli...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular...
TMPJ-00441	CDH1 Protein, Human, Recombinant (His) CDH1 protein,CDH1	Human	HEK293 Cells
	Cdh1 is one of the substrate adaptor protein of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate specificity of this ubiquitin E3-ligase.
TMPH-03074	UBC5A Protein, Japonica rice, Recombinant (His & Myc)	Rice	E. coli
	E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins. UBC5A Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.6 kDa and the accession number is Q8S920.
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc) C4orf30,DCAF16,DDB1- and CUL4-associated factor 16	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q9NXF7.
TMPH-03391	TRIM2 Protein, Rat, Recombinant (His)	Rat	E. coli
	E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6.
TMPH-01265	PELI3 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access...
TMPH-01220	DDA1 Protein, Human, Recombinant (His) Placenta cross-immune reaction antigen 1,DET1- and DDB1-asso...	Human	E. coli
	Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. DDA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9BW61.
TMPH-03508	IpaH9.8 Protein, Shigella flexneri, Recombinant (His)	Shigella flexneri	P. pastoris (Yeast)
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0.
TMPH-02208	TRAF3 Protein, Human, Recombinant	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga...
TMPJ-01133	NEDD8 Protein, Human, Recombinant (His & SUMO) Neddylin,Ubiquitin-like protein Nedd8,NEDD...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHi...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPH-01269	SMURF2 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com...
TMPJ-01013	VCP Protein, Human, Recombinant (His) TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...
TMPK-00045	SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated SIII,OCP-2,TCEB1L,EMC19,OCP-II,OCP2,SKP1A,p19A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21....
TMPY-04149	RNF43 Protein, Human, Recombinant (hFc) RNF43,RNF124,URCC,ring finger protein 43	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and t...
TMPH-01205	DCAF7 Protein, Human, Recombinant (His) DDB1- and CUL4-associated factor 7,WDR68,DCAF7,WD repeat-con...	Human	E. coli
	Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPK-01298	BST2 Protein, Cynomolgus, Recombinant (His) HM1.24 antigen,PDCA-1,BST2,TETHERIN,BST-2,NPC-A-7,CD317	Cynomolgus	HEK293 Cells
	Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.
TMPK-00044	SKP1 Protein, Human, Recombinant (His, Avi) OCP-II,TCEB1L,SIII,p19A,OCP-2,EMC19,OCP2,SKP1A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi) is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21.43 kDa and the...
TMPH-01272	TRIM9 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
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重组蛋白

UBE2G2 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01035

Species: Human

Expression System: E. coli

Pellino-1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00361

Species: Human

Expression System: Baculovirus Insect Cells

UBE2I Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01053

Species: Human

Expression System: E. coli

RNF43 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01001

Species: Mouse

Expression System: HEK293 Cells

UBE2H Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01047

Species: Human

Expression System: E. coli

UBE2D4 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01403

Species: Human

Expression System: E. coli

UBE2R2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01198

Species: Human

Expression System: E. coli

UBE2A Protein, Human, Recombinant (GST, His)

Cat.No: TMPJ-00985

Species: Human

Expression System: E. coli

UBE2S Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01138

Species: Human

Expression System: E. coli

UBE2Z Protein, Human, Recombinant (His)

Cat.No: TMPJ-01334

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant

Cat.No: TMPJ-00571

Species: Human

Expression System: E. coli

UBE2K Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPJ-01039

Species: Human

Expression System: E. coli

UBE2B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00033

Species: Human

Expression System: HEK293 Cells

UBE2K Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01038

Species: Human

Expression System: E. coli

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

Cbl-c Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03510

Species: Human

Expression System: Baculovirus Insect Cells

WWP2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02950

Species: Human

Expression System: Baculovirus Insect Cells

UBE2D1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00999

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (His)

Cat.No: TMPH-01259

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01260

Species: Human

Expression System: HEK293 Cells

STUB1 Protein, Human, Recombinant

Cat.No: TMPJ-01386

Species: Human

Expression System: E. coli

VHL Protein, Human, Recombinant (His & Avi)

Cat.No: TMPY-06026

Species: Human

Expression System: E. coli

XIAP Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01216

Species: Human

Expression System: E. coli

XIAP Protein, Human, Recombinant (His)

Cat.No: TMPY-02922

Species: Human

Expression System: E. coli

SPSB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02136

Species: Human

Expression System: E. coli

RNF43 Protein, Human, Recombinant (His)

Cat.No: TMPY-04153

Species: Human

Expression System: HEK293 Cells

DCAF4 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01204

Species: Human

Expression System: E. coli

FBXO44 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01326

Species: Human

Expression System: E. coli

Cap8A Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03526

Species: Staphylococcus aureus

Expression System: E. coli

Fbxo3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02651

Species: Mouse

Expression System: E. coli

NEDD8 Protein, Human, Recombinant

Cat.No: TMPJ-01132

Species: Human

Expression System: E. coli

CDH1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00441

Species: Human

Expression System: HEK293 Cells

UBC5A Protein, Japonica rice, Recombinant (His & Myc)

Cat.No: TMPH-03074

Species: Rice

Expression System: E. coli

DCAF16 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01203

Species: Human

Expression System: E. coli

TRIM2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03391

Species: Rat

Expression System: E. coli

PELI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01265

Species: Human

Expression System: E. coli

DDA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01220

Species: Human

Expression System: E. coli

IpaH9.8 Protein, Shigella flexneri, Recombinant (His)

Cat.No: TMPH-03508

Species: Shigella flexneri

Expression System: P. pastoris (Yeast)

TRAF3 Protein, Human, Recombinant

Cat.No: TMPH-02208

Species: Human

Expression System: E. coli

NEDD8 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPJ-01133

Species: Human

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

SMURF2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01269

Species: Human

Expression System: E. coli

VCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01013

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-00045

Species: Human

Expression System: HEK293 Cells

RNF43 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04149

Species: Human

Expression System: HEK293 Cells

DCAF7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01205

Species: Human

Expression System: E. coli

BST2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01298

Species: Cynomolgus

Expression System: HEK293 Cells

SKP1 Protein, Human, Recombinant (His, Avi)

Cat.No: TMPK-00044

Species: Human

Expression System: HEK293 Cells

TRIM9 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01272

Species: Human

Expression System: E. coli

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

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